PSEN2 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 11001931)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		PSEN2	FHL2
Description		presenilin 2	four and a half LIM domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nucleus Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Synaptic Vesicle Cell Surface Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Neuromuscular Junction Protein-containing Complex Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Integral Component Of Presynaptic Membrane	Nucleus Nucleoplasm Focal Adhesion Z Disc M Band
	Molecular Function	Endopeptidase Activity Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Response To Hypoxia Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Notch Receptor Processing, Ligand-dependent Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Ephrin Receptor Signaling Pathway Amyloid-beta Metabolic Process Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Response To Hormone Regulation Of Lipid Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3	PPARA activates gene expression
Drugs
Diseases		Alzheimer's disease (AD)
GWAS		Heel bone mineral density ( 30598549)	Body fat mass ( 28552196) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 30224653 30578418)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	98 interacting genes: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BIN1 BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HCK HSPB2 ID3 IDH1 IER3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MDM2 MYBPC1 NIBAN1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SAXO1 SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 SUMO1P1 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		5664	2274
HPRD ID		02860	04026
Ensembl ID		ENSG00000143801	ENSG00000115641
Uniprot IDs		P49810	Q14192 Q2XQU9 Q6I9R8
PDB IDs			1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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