PSEN2 and NOTCH1

  • Number of citations of the paper that reports this interaction (PubMedID 11518718)
  • 45
  • Data Source:
  • HPRD (in vivo)

PSEN2

NOTCH1

Description presenilin 2 notch receptor 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
  • Crohn's disease ( 28067908)
  • Inflammatory bowel disease ( 28067908)
  • Length of menstrual cycle ( 26732621)
  • Red cell distribution width ( 28957414)
  • Ulcerative colitis ( 28067908)
Interacting Genes 61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1 82 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 C9orf62 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MDM2 MEF2C MFNG NFKB1 NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SMAD3 SNAI1 SNW1 TLE3 TOR1A USP10 USP12 USP2 USP7 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID 5664 4851
HPRD ID 02860 01827
Ensembl ID ENSG00000143801 ENSG00000148400
Uniprot IDs P49810 P46531
PDB IDs 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8
Enriched GO Terms of Interacting Partners?
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