ALS2 and IMPDH2

		ALS2	IMPDH2
Description		alsin Rho guanine nucleotide exchange factor ALS2	inosine monophosphate dehydrogenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Early Endosome Centrosome Cytosol Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Neuronal Cell Body Dendritic Spine	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Behavioral Fear Response In Utero Embryonic Development Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Axonogenesis Neuromuscular Junction Development Locomotory Behavior Protein Localization Cell Death Endosomal Transport Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4
Pathways		RAB GEFs exchange GTP for GDP on RABs	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB	24 interacting genes: AKT1 ALS2 AMT ANKRD9 APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 KLF7 PIAS4 PRMT1 PXMP2 PXN RAD54L2 RBM15B SUMO4 UBQLN4
Entrez ID		57679	3615
HPRD ID		05893	00895
Ensembl ID		ENSG00000003393	ENSG00000178035
Uniprot IDs		A8K4R4 Q96Q42	A0A384N6C2 P12268
PDB IDs			1B3O 1NF7 1NFB 6I0M 6I0O
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?