IMPDH2 and FBXL7

		IMPDH2	FBXL7
Description		inosine monophosphate dehydrogenase 2	F-box and leucine rich repeat protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Ubiquitin Ligase Complex Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cell Division
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)
Interacting Genes		24 interacting genes: AKT1 ALS2 AMT ANKRD9 APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 KLF7 PIAS4 PRMT1 PXMP2 PXN RAD54L2 RBM15B SUMO4 UBQLN4	4 interacting genes: APP BIRC5 FBXL18 IMPDH2
Entrez ID		3615	23194
HPRD ID		00895	05740
Ensembl ID		ENSG00000178035	ENSG00000183580
Uniprot IDs		A0A384N6C2 P12268	Q9UJT9
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O
Enriched GO Terms of Interacting Partners?
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