ALS2 and PPIL3

		ALS2	PPIL3
Description		alsin Rho guanine nucleotide exchange factor ALS2	peptidylprolyl isomerase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Early Endosome Centrosome Cytosol Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Neuronal Cell Body Dendritic Spine	Catalytic Step 2 Spliceosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	Behavioral Fear Response In Utero Embryonic Development Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Axonogenesis Neuromuscular Junction Development Locomotory Behavior Protein Localization Cell Death Endosomal Transport Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways		RAB GEFs exchange GTP for GDP on RABs	mRNA Splicing - Major Pathway
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB	15 interacting genes: ALS2 CDK11B MAIP1 MOB4 NOP58 NUP107 PCBP1 SHARPIN SLU7 SPATS2L SRPK1 STRADB TAB2 TAB3 WDR12
Entrez ID		57679	53938
HPRD ID		05893	15163
Ensembl ID		ENSG00000003393	ENSG00000240344
Uniprot IDs		A8K4R4 Q96Q42	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs			1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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