ALS2 and SUN2

		ALS2	SUN2
Description		alsin Rho guanine nucleotide exchange factor ALS2	Sad1 and UNC84 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Early Endosome Centrosome Cytosol Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Neuronal Cell Body Dendritic Spine	Nuclear Chromosome, Telomeric Region Condensed Nuclear Chromosome Cell Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein Membrane Anchor
	Biological Process	Behavioral Fear Response In Utero Embryonic Development Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Axonogenesis Neuromuscular Junction Development Locomotory Behavior Protein Localization Cell Death Endosomal Transport Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		RAB GEFs exchange GTP for GDP on RABs	Meiotic synapsis
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)	Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB	14 interacting genes: ALS2 APOBEC3C HGS MAFF MUC16 NRM PAEP PSMC2 RAB5B RASD2 RGS2 RPS20 SH3BP1 TXN2
Entrez ID		57679	25777
HPRD ID		05893	15611
Ensembl ID		ENSG00000003393	ENSG00000100242
Uniprot IDs		A8K4R4 Q96Q42	A0A024R1P7 B4E2A6 Q9UH99
PDB IDs			3UNP 4DXR 4DXS 4DXT 4FI9
Enriched GO Terms of Interacting Partners?
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