IMPDH2 and DNASE1L3

		IMPDH2	DNASE1L3
Description		inosine monophosphate dehydrogenase 2	deoxyribonuclease 1 like 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Nucleus Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding	DNA Binding Deoxyribonuclease I Activity Deoxyribonuclease Activity Calcium Ion Binding
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4	DNA Catabolic Process, Endonucleolytic Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Programmed Cell Death Involved In Cell Development Regulation Of Neutrophil Mediated Cytotoxicity
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Eating disorders (purging via substances) ( 23568457) Height ( 28552196) Limited cutaneous systemic scleroderma ( 24387989) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic sclerosis ( 28314753 24387989 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		24 interacting genes: AKT1 ALS2 AMT ANKRD9 APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 KLF7 PIAS4 PRMT1 PXMP2 PXN RAD54L2 RBM15B SUMO4 UBQLN4	1 interacting genes: IMPDH2
Entrez ID		3615	1776
HPRD ID		00895	03764
Ensembl ID		ENSG00000178035	ENSG00000163687
Uniprot IDs		A0A384N6C2 P12268	A0A024R365 Q13609
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O
Enriched GO Terms of Interacting Partners?
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