IMPDH2 and CEACAM5

		IMPDH2	CEACAM5
Description		inosine monophosphate dehydrogenase 2	CEA cell adhesion molecule 5
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Anchored Component Of Membrane Extracellular Exosome Integral Component Of External Side Of Plasma Membrane
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding	GPI Anchor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4	Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Myotube Differentiation Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Leukocyte Migration Negative Regulation Of Anoikis
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis	Post-translational modification: synthesis of GPI-anchored proteins Cell surface interactions at the vascular wall
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148	S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Serum carcinoembryonic antigen levels ( 31666285)
Interacting Genes		24 interacting genes: AKT1 ALS2 AMT ANKRD9 APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 KLF7 PIAS4 PRMT1 PXMP2 PXN RAD54L2 RBM15B SUMO4 UBQLN4	7 interacting genes: CEACAM1 CEACAM6 DISP3 EWSR1 HNRNPM IMPDH2 UQCC2
Entrez ID		3615	1048
HPRD ID		00895	00274
Ensembl ID		ENSG00000178035	ENSG00000105388
Uniprot IDs		A0A384N6C2 P12268	A0A024R0K5 P06731 Q53G30
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O	1E07 2QSQ 2QST 2VER
Enriched GO Terms of Interacting Partners?
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