VARS2 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		VARS2	SORBS3
Description		valyl-tRNA synthetase 2, mitochondrial	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Aminoacyl-tRNA Editing Activity Valine-tRNA Ligase Activity ATP Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Mitochondrial tRNA aminoacylation	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Conotruncal heart defects (maternal effects) ( 28468790) Gestational age at birth (maternal effect) ( 28877031) HIV-1 control ( 20041166) Microalbuminuria in type 1 diabetes ( 31537649) Pubertal anthropometrics ( 23449627) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 20848476) Urate levels ( 31578528)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		6 interacting genes: ABI2 CMTM5 MAL2 NCK2 PIK3CA SORBS3	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		57176	10174
HPRD ID		11670	11535
Ensembl ID		ENSG00000137411	ENSG00000120896
Uniprot IDs		A0A1U9X9B3 B4DG77 B4E0K6 Q5ST30	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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