OTUB2 and RFFL

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		OTUB2	RFFL
Description		OTU deubiquitinase, ubiquitin aldehyde binding 2	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleus	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Binding	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Ovarian tumor domain proteases	Regulation of TP53 Degradation
Drugs
Diseases
GWAS			Acute post-radiotherapy pain in breast cancer ( 31196165) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		35 interacting genes: APP ARRDC3 CPSF6 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28	21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		78990	117584
HPRD ID		07620	11489
Ensembl ID		ENSG00000089723	ENSG00000092871
Uniprot IDs		Q96DC9	Q8WZ73
PDB IDs		1TFF 4FJV	1Y02
Enriched GO Terms of Interacting Partners?
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