OTUB2 and USP21

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		OTUB2	USP21
Description		OTU deubiquitinase, ubiquitin aldehyde binding 2	ubiquitin specific peptidase 21
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GO Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Binding	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		Ovarian tumor domain proteases	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes		35 interacting genes: APP ARRDC3 CPSF6 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28	54 interacting genes: ATXN3 AURKA BAP1 BRCA2 CBL CBLC DTX3 ESPL1 EXOSC10 FOXM1 H2AC18 ISG15 JOSD1 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		78990	27005
HPRD ID		07620	05291
Ensembl ID		ENSG00000089723	ENSG00000143258
Uniprot IDs		Q96DC9	Q9UK80
PDB IDs		1TFF 4FJV	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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