MAGI2 and PLXNB3

Data Source:
HPRD (two hybrid)

		MAGI2	PLXNB3
Description		membrane associated guanylate kinase, WW and PDZ domain containing 2	plexin B3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Dendrite Protein-containing Complex Slit Diaphragm Synapse Perinuclear Region Of Cytoplasm	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways		Nephrin family interactions	Other semaphorin interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to anti-depressant treatment in major depressive disorder ( 22041458) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 30285260) Serum folate levels ( 29953918) Visceral fat ( 30942860)
Interacting Genes		24 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAML1 GRID2 MORN4 PDZD11 PLEKHF2 PLXNB3 PTEN RAPGEF2 RPS6KA1 SMAD3 SNRPB TGFA	8 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		9863	5365
HPRD ID		16212	02198
Ensembl ID		ENSG00000187391	ENSG00000198753
Uniprot IDs		B7Z4H4 Q86UL8	A8K920 Q9ULL4
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?
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