MAGI2 and ATN1

Data Source:
HPRD (in vitro, two hybrid)

		MAGI2	ATN1
Description		membrane associated guanylate kinase, WW and PDZ domain containing 2	atrophin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Dendrite Protein-containing Complex Slit Diaphragm Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding	RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Neuron Apoptotic Process
Pathways		Nephrin family interactions	Regulation of PTEN gene transcription
Drugs
Diseases			Dentatorubropallidoluysian atrophy (DRPLA)
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to anti-depressant treatment in major depressive disorder ( 22041458) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 30285260) Serum folate levels ( 29953918) Visceral fat ( 30942860)	Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAML1 GRID2 MORN4 PDZD11 PLEKHF2 PLXNB3 PTEN RAPGEF2 RPS6KA1 SMAD3 SNRPB TGFA	121 interacting genes: AGRN ALG13 ARF3 ATRX BAG3 BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CSNK2A1 CTNND2 DGCR6L DMPK DMRT3 DVL1 DVL2 ECM1 EFEMP1 EFEMP2 ETNK2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HGS HINFP HNRNPF HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP12-2 KRTAP15-1 KRTAP19-2 KRTAP19-5 KRTAP4-12 KRTAP6-2 KRTAP9-3 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 OLIG3 P4HA3 PCSK5 PDCD6IP PFKL PIN1 PITX1 PITX2 PLSCR1 PPP1R32 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBM14 RBM4B RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SH3RF1 SIAH1 SIAH2 SLC25A48 SLIT1 SPAG5 SS18L1 SSPOP STXBP4 SYVN1 TEKT3 TEP1 TLE1 TLE5 TNFAIP8 TRIP6 USP2 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZNF503 ZSWIM8
Entrez ID		9863	1822
HPRD ID		16212	06311
Ensembl ID		ENSG00000187391	ENSG00000111676
Uniprot IDs		B7Z4H4 Q86UL8	P54259 Q86V38
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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