CDK1 and SQSTM1

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology)

		CDK1	SQSTM1
Description		cyclin dependent kinase 1	sequestosome 1
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin B1-CDK1 Complex	Phagophore Assembly Site P-body Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Intracellular Membrane-bounded Organelle Amphisome Autolysosome Extracellular Exosome Sperm Midpiece Lewy Body
	Molecular Function	Virus Receptor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Activation Of MAPK Activity Microtubule Cytoskeleton Organization DNA Replication DNA Repair Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Nuclear Envelope Disassembly Mitotic G2 DNA Damage Checkpoint Centrosome Cycle Pronuclear Fusion Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Cell Migration Histone Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Epithelial Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Embryonic Development Viral Entry Into Host Cell Rhythmic Process Cell Division Golgi Disassembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Positive Regulation Of Protein Phosphorylation Immune System Process Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Apoptotic Process Endosome Organization Protein Localization Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Selective Autophagy Interleukin-1-mediated Signaling Pathway Response To Mitochondrial Depolarisation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerisation of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2	NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Interleukin-1 signaling Pexophagy
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib
Diseases			Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Cocaine dependence ( 23958962) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)	Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		186 interacting genes: ABL1 AMPH APLP2 AR ARID4A BARD1 BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN1B CDKN3 CDT1 CEP55 CEP63 CHAF1B CIITA CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EGFR EP300 EPN1 ERCC2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN GADD45A GADD45B GADD45G GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MARCKS MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PPP2R2B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UBE3A UHRF2 USP16 VIM WEE1 XIAP ZBTB16	106 interacting genes: ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNB1 CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 CSNK2A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 EEF1D FKBP4 GABARAP GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 HSPB1 IKBKB IRAK1 ISG15 KAT5 KCNAB2 KEAP1 LCK LINC01554 LRRK2 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MTDH NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 PADI1 PAWR PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TBK1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIB3 TRIM21 TRIM55 TRIM63 TTN UBA52 UBB UBC UBE2D2 UBE2D3 ULK2 VANGL2 WDR81 XIAP YWHAZ
Entrez ID		983	8878
HPRD ID		00302	03319
Ensembl ID		ENSG00000170312	ENSG00000161011
Uniprot IDs		A0A024QZJ8 B7Z3D6 I6L9I5 P06493	Q13501
PDB IDs		1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7	1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3
Enriched GO Terms of Interacting Partners?
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