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SQSTM1 and RPL37
Data Source:
BioGRID
(two hybrid)
SQSTM1
RPL37
Description
sequestosome 1
ribosomal protein L37
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Extracellular Exosome
Sperm Midpiece
Lewy Body
Cytosol
Cytosolic Large Ribosomal Subunit
Synapse
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
RNA Binding
Structural Constituent Of Ribosome
RRNA Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Positive Regulation Of Protein Phosphorylation
Immune System Process
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Apoptotic Process
Endosome Organization
Protein Localization
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Selective Autophagy
Interleukin-1-mediated Signaling Pathway
Response To Mitochondrial Depolarisation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Interleukin-1 signaling
Pexophagy
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
(S)-3-phenyllactic acid
PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE
Virginiamycin S1
Anisomycin
Puromycin
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
106 interacting genes:
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNB1
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
CSNK2A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
EEF1D
FKBP4
GABARAP
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
HSPB1
IKBKB
IRAK1
ISG15
KAT5
KCNAB2
KEAP1
LCK
LINC01554
LRRK2
MALT1
MAP1LC3A
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MTDH
NBR1
NCOR1
NR2F2
NTRK1
NTRK2
NTRK3
PADI1
PAWR
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TBK1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIB3
TRIM21
TRIM55
TRIM63
TTN
UBA52
UBB
UBC
UBE2D2
UBE2D3
ULK2
VANGL2
WDR81
XIAP
YWHAZ
6 interacting genes:
APP
POLR1B
SQSTM1
SRPK2
TCF3
WIF1
Entrez ID
8878
6167
HPRD ID
03319
16047
Ensembl ID
ENSG00000161011
ENSG00000145592
Uniprot IDs
Q13501
P61927
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
4UG0
4V6X
5AJ0
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
Enriched GO Terms of Interacting Partners
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