Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CDK1 and GOLGA2
Data Source:
HPRD
(in vivo, in vitro)
CDK1
GOLGA2
Description
cyclin dependent kinase 1
golgin A2
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Golgi Cis Cisterna
Golgi Membrane
Spindle Pole
Golgi Apparatus
Cis-Golgi Network
Microtubule
COPII-coated ER To Golgi Transport Vesicle
Golgi Cisterna Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Mitotic Spindle
Molecular Function
Virus Receptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Protein Binding
Microtubule Binding
Protein Kinase Binding
Syntaxin Binding
Identical Protein Binding
Cadherin Binding
Importin-alpha Family Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Nuclear Envelope Disassembly
Mitotic G2 DNA Damage Checkpoint
Centrosome Cycle
Pronuclear Fusion
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Epithelial Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Embryonic Development
Viral Entry Into Host Cell
Rhythmic Process
Cell Division
Golgi Disassembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Protein Glycosylation
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Microtubule Nucleation
Golgi Organization
Centrosome Cycle
Asymmetric Cell Division
Negative Regulation Of Autophagy
Protein Transport
Negative Regulation Of Protein Binding
COPII Vesicle Coating
Spindle Assembly
Protein Homotetramerization
Positive Regulation Of Protein Glycosylation
Golgi Ribbon Formation
Golgi Disassembly
Spindle Assembly Involved In Meiosis
Mitotic Spindle Assembly
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
COPII-mediated vesicle transport
COPI-mediated anterograde transport
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Diseases
GWAS
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Adult body size (
32376654
)
Body mass index (
26426971
)
Interacting Genes
186 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN1B
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MARCKS
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
461 interacting genes:
ABHD17A
ABLIM1
ADAP1
AFF4
ALKBH2
ALKBH3
AMOTL2
ANKHD1
ANKRD11
ANKRD36
ANKRD36BP1
ANKS1A
APC
AQP1
ARFIP2
ARHGAP45
ARHGEF6
ARID5A
ARL16
ARL4A
ARNT2
ARPC3
ATP5PO
ATP6V1C2
ATP6V1D
ATP6V1G1
ATXN7
AXIN1
BAHD1
BARD1
BAZ2B
BCAS2
BCL6
BCL6B
BMS1P1
BYSL
C12orf50
C19orf44
C1orf109
C1orf35
C2CD6
CAB39
CAPN7
CBX8
CBY2
CCAR1
CCDC120
CCDC13
CCDC146
CCDC150
CCDC17
CCDC185
CCDC187
CCDC198
CCDC70
CCDC87
CCDC92
CCHCR1
CCNC
CCNH
CDC20B
CDC37
CDC5L
CDC7
CDC73
CDCA7L
CDK1
CDK18
CDKL3
CDKN1A
CENPP
CEP55
CEP57L1
CEP95
CHCHD2
CHCHD3
CIC
CINP
CKB
CLIP3
COG6
CORO1A
COX5B
CRACR2A
CRMP1
CSPP1
CSTF2T
CUL5
CWF19L2
CYB5R2
DAXX
DCTN4
DCX
DDX6
DEUP1
DGCR6
DLGAP3
DLGAP5
DLX6-AS1
DMTN
DNM2
DTX2
DVL2
EAF2
EFCAB6
EFHC1
EGR2
EIF3G
EIF4A2
ENKD1
ENPP7
EP300
ERCC3
ESCO2
EXOC8
EXOSC5
FAM110A
FAM124B
FAM126B
FAM161A
FAM161B
FAM184A
FAM193B
FAM207A
FAM214A
FAM214B
FAM50B
FAM90A1
FANCG
FBF1
FBXL18
FBXO28
FIP1L1
FNDC11
FOXC2
GADD45GIP1
GAS2L2
GAS8
GATA1
GATA2
GATAD2B
GCC1
GEM
GFAP
GGA2
GGN
GLYCTK
GMCL1
GNG5
GNL3L
GORASP1
GORASP2
GPANK1
GPKOW
GPS2
GRAP2
GRB14
GSE1
GTPBP10
GZMA
GZMK
HAUS1
HDAC4
HGS
HOXB5
HOXB9
HTRA1
HYLS1
IFT20
IFT27
IGFN1
IHO1
IKZF3
IL16
INPP5J
IQCE
IQUB
ISCU
ITGB5
ITPKB
ITSN2
KANK2
KANSL1
KAT5
KDM1A
KIAA1217
KIFC3
KRT1
KRT18
KRT6A
KRT6B
KRT6C
KRT75
L3MBTL2
LASP1
LATS1
LCOR
LCP2
LENG1
LGALS3
LHX4
LIMS2
LIN7A
LINGO1
LMNB2
LMO1
LMO2
LMO3
LMO4
LYPLA1
LYSMD1
MAB21L2
MAGOH
MAGOHB
MBD3
MCM10
MCM7
MCRS1
MFAP1
MID2
MISP
MNAT1
MORF4L1
MORF4L2
MORN3
MOS
MSRB3
MTFR2
MVP
MYEF2
NCF2
NDC80
NDE1
NDEL1
NDN
NDUFA5
NEBL
NECAB2
NEFL
NME7
NOS3
NOTCH1
NSMF
NTAQ1
NUDT21
NXT2
OAS1
ODAD4
ORC1
PACRGL
PARD6B
PATL1
PCM1
PIAS2
PIBF1
PID1
PIK3R2
PIMREG
PIN1
PITX1
PKN1
PKN3
PKP1
PKP2
PKP4
PLAAT5
PLEKHA2
POLDIP3
POLR3C
POM121
POU4F3
PPP1R16B
PPP1R18
PPP1R32
PPP2CA
PQBP1
PRAM1
PRKAA1
PRKAA2
PRKAB2
PRPF18
PRPF3
PRPF31
PSMA1
PSMA4
PTBP2
PTPN11
PTPN21
RAB1A
RAB1B
RAB2A
RAB2B
RAB33B
RAB39A
RAB39B
RAB6A
RAD18
RAMAC
RANBP3
RANBP3L
RBL1
RBM17
RBM22
RBM25
RBM39
RBM41
RCL1
RCOR3
RGS8
RHNO1
RHOJ
RHPN1
RIBC1
RIN1
RITA1
RNF135
RNF169
RNF213
RNF214
RNF6
RSPH14
RSRC2
RTP5
RUSC2
RXRB
SAMD4A
SAP30BP
SCAF8
SCEL
SCNM1
SECISBP2
SELENOV
SFI1
SH2D4A
SH3GLB2
SH3RF2
SHC3
SHISA6
SLU7
SMARCB1
SMARCE1
SMCP
SMG9
SNAP47
SNF8
SNRPB
SNRPB2
SNRPC
SNTA1
SNW1
SNX18
SORBS2
SPATA18
SPATA2
SPATA22
SPG21
SRSF2
SSX2IP
STAC
STAMBPL1
STK25
STK26
STN1
SUDS3
SUGP2
SUPT5H
SYNPO2L
SYT17
SYT6
TBC1D22B
TBC1D30
TBP
TCEA2
TCEANC
TCF19
TCL1A
TDP2
TEAD4
TEPSIN
TEX9
TFAP4
TFIP11
THAP7
THYN1
TLE5
TMED2
TPM1
TPRX1
TPX2
TRAF1
TRAF3IP2
TRAF4
TRAF5
TRIM14
TRIM29
TRIM42
TSC22D4
TSGA10
TSGA10IP
TSHZ2
TSHZ3
TSSC4
TSSK3
TTC23
TTC9C
TTPA
TUBGCP4
TXLNA
TXLNB
UBE2H
UBE2I
UBE2U
UBE3C
UBTFL1
USO1
USP15
USP2
UTP14C
UTP23
VPS28
VPS37C
WASHC3
WHRN
WT1
XIAP
YJU2
YTHDC1
ZBTB16
ZBTB4
ZBTB42
ZC2HC1C
ZFC3H1
ZFHX3
ZFP2
ZFYVE26
ZG16B
ZGPAT
ZMAT1
ZMAT2
ZNF124
ZNF250
ZNF280C
ZNF3
ZNF35
ZNF410
ZNF414
ZNF417
ZNF438
ZNF48
ZNF488
ZNF512B
ZNF524
ZNF572
ZNF581
ZNF587
ZNF594
ZNF648
ZNF688
ZNF774
ZNF835
ZZZ3
Entrez ID
983
2801
HPRD ID
00302
03989
Ensembl ID
ENSG00000170312
ENSG00000167110
Uniprot IDs
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
Q08379
PDB IDs
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
4REY
6IW8
6IWA
6K06
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?