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CDK1 and ABL1
Data Source:
HPRD
(in vivo, in vitro)
CDK1
ABL1
Description
cyclin dependent kinase 1
ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Nuclear Body
Dendrite
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Molecular Function
Virus Receptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Nuclear Envelope Disassembly
Mitotic G2 DNA Damage Checkpoint
Centrosome Cycle
Pronuclear Fusion
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Epithelial Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Embryonic Development
Viral Entry Into Host Cell
Rhythmic Process
Cell Division
Golgi Disassembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Positive Regulation Of Protein Phosphorylation
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Protein Phosphorylation
Endocytosis
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Establishment Of Protein Localization
Regulation Of T Cell Differentiation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Protein Autophosphorylation
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Stress Fiber Assembly
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Circulatory System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Actin Filament Branching
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Microtubule Binding
Positive Regulation Of Actin Filament Binding
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Blood Vessel Branching
Activation Of Protein Kinase C Activity
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Pathways
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
PD-166326
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Fostamatinib
Brigatinib
Radotinib
Diseases
Chronic myeloid leukemia (CML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Response to amphetamines (
22952603
)
White blood cell count (
32888494
)
Interacting Genes
186 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN1B
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MARCKS
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
161 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
AR
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
FBXO7
GJA8
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
KRT31
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
Entrez ID
983
25
HPRD ID
00302
01809
Ensembl ID
ENSG00000170312
ENSG00000097007
Uniprot IDs
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
A0A024R8E2
P00519
Q59FK4
PDB IDs
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
6XR6
6XR7
6XRG
Enriched GO Terms of Interacting Partners
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