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SQSTM1 and MAPK13
Data Source:
BioGRID
(enzymatic study)
SQSTM1
MAPK13
Description
sequestosome 1
mitogen-activated protein kinase 13
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Extracellular Exosome
Sperm Midpiece
Lewy Body
Nucleus
Cytoplasm
Cytosol
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Positive Regulation Of Protein Phosphorylation
Immune System Process
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Apoptotic Process
Endosome Organization
Protein Localization
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Selective Autophagy
Interleukin-1-mediated Signaling Pathway
Response To Mitochondrial Depolarisation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Response To Osmotic Stress
Cell Cycle
Peptidyl-serine Phosphorylation
Positive Regulation Of Interleukin-6 Production
Cellular Response To UV
Intracellular Signal Transduction
Positive Regulation Of Inflammatory Response
Stress-activated MAPK Cascade
Cellular Response To Hydrogen Peroxide
Cellular Response To Interleukin-1
Cellular Response To Sorbitol
Cellular Response To Anisomycin
Cellular Response To Sodium Arsenite
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Interleukin-1 signaling
Pexophagy
NOD1/2 Signaling Pathway
p38MAPK events
DSCAM interactions
VEGFA-VEGFR2 Pathway
Drugs
Minocycline
KC706
Fostamatinib
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Birth weight (
31043758
)
Blood protein levels (
30072576
29875488
)
Offspring birth weight (
31043758
)
Interacting Genes
106 interacting genes:
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNB1
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
CSNK2A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
EEF1D
FKBP4
GABARAP
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
HSPB1
IKBKB
IRAK1
ISG15
KAT5
KCNAB2
KEAP1
LCK
LINC01554
LRRK2
MALT1
MAP1LC3A
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MTDH
NBR1
NCOR1
NR2F2
NTRK1
NTRK2
NTRK3
PADI1
PAWR
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TBK1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIB3
TRIM21
TRIM55
TRIM63
TTN
UBA52
UBB
UBC
UBE2D2
UBE2D3
ULK2
VANGL2
WDR81
XIAP
YWHAZ
16 interacting genes:
AKIP1
ANKLE2
APP
ATF2
EEF2K
FGF12
GPX4
HTRA2
MAP2K6
MAP3K4
MAPKAPK3
MAPKAPK5
MAPT
MBP
SMAD4
SQSTM1
Entrez ID
8878
5603
HPRD ID
03319
09113
Ensembl ID
ENSG00000161011
ENSG00000156711
Uniprot IDs
Q13501
A0A024RD04
O15264
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
3COI
4EYJ
4EYM
4MYG
4YNO
5EKN
5EKO
Enriched GO Terms of Interacting Partners
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