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CD74 and MIF
Data Source:
HPRD
(in vivo, in vitro)
CD74
MIF
Description
CD74 molecule
macrophage migration inhibitory factor
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Extracellular Region
Extracellular Space
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Vesicle
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Folding Chaperone
Nitric-oxide Synthase Binding
Dopachrome Isomerase Activity
Cytokine Activity
Cytokine Receptor Binding
Protein Binding
Chemoattractant Activity
Identical Protein Binding
Phenylpyruvate Tautomerase Activity
Biological Process
Activation Of MAPK Activity
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
T Cell Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Cell Population Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Kinase Activity
Response To Interferon-gamma
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Prostaglandin Biosynthetic Process
Positive Regulation Of Cytokine Production
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Gene Expression
Positive Regulation Of Protein Kinase A Signaling
Negative Regulation Of Macrophage Chemotaxis
Carboxylic Acid Metabolic Process
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Interleukin-12-mediated Signaling Pathway
Positive Regulation Of Phosphorylation
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Innate Immune Response
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Chemotaxis
Protein Homotrimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Cycle Arrest
Negative Regulation Of Cell Aging
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Cell surface interactions at the vascular wall
MHC class II antigen presentation
Cell surface interactions at the vascular wall
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
3,4-Dihydroxycinnamic Acid
7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester
4-Hydroxyphenylpyruvic acid
3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Blood protein levels (
30072576
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Macrophage Migration Inhibitory Factor levels (
27989323
)
Interacting Genes
44 interacting genes:
APP
BET1
C14orf180
CCR1
CD1D
CD44
CLDN19
CLEC7A
CMTM7
CTSF
CTSL
EDDM3B
ERG28
FDFT1
FXYD6
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
LPAR3
MAP3K1
MIF
PGA4
PLP1
PLPP4
POMGNT1
PTCH1
RTP2
SEC22A
SERP1
SLC35B1
SMIM1
TEX11
TMEM120B
TMEM243
TMEM254
TMEM60
TMEM97
UPK2
13 interacting genes:
BEX3
BNIPL
CD74
COPS5
COPS6
EGFR
GORASP2
NME1
NTAQ1
STRN4
TP53
UPF2
ZNF408
Entrez ID
972
4282
HPRD ID
00825
01091
Ensembl ID
ENSG00000019582
ENSG00000240972
Uniprot IDs
P04233
I4AY87
P14174
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
1CA7
1CGQ
1GCZ
1GD0
1GIF
1LJT
1MIF
1P1G
2OOH
2OOW
2OOZ
3B9S
3CE4
3DJH
3DJI
3HOF
3IJG
3IJJ
3JSF
3JSG
3JTU
3L5P
3L5R
3L5S
3L5T
3L5U
3L5V
3SMB
3SMC
3U18
3WNR
3WNS
3WNT
4ETG
4EUI
4EVG
4F2K
4GRN
4GRO
4GRP
4GRQ
4GRR
4GRU
4GUM
4K9G
4OSF
4OYQ
4P01
4P0H
4PKK
4PKZ
4PLU
4TRF
4TRU
4WR8
4WRB
4XX7
4XX8
4Z15
4Z1T
4Z1U
5B4O
5BS9
5BSC
5BSI
5BSJ
5EIZ
5HVS
5HVT
5HVV
5J7P
5J7Q
5UMJ
5UMK
5UZY
5V70
5V73
5XEJ
6B1C
6B1K
6B2C
6BG6
6BG7
6CB5
6CBF
6CBG
6CBH
6FVE
6FVH
6OY8
6OYB
6OYE
6OYG
6PEG
Enriched GO Terms of Interacting Partners
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