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CD74 and CTSL
Data Source:
HPRD
(in vitro)
CD74
CTSL
Description
CD74 molecule
cathepsin L
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Extracellular Region
Extracellular Space
Nucleus
Lysosome
Multivesicular Body
Golgi Apparatus
Plasma Membrane
Apical Plasma Membrane
Endolysosome Lumen
Chromaffin Granule
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Folding Chaperone
Nitric-oxide Synthase Binding
Fibronectin Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Collagen Binding
Cysteine-type Peptidase Activity
Histone Binding
Proteoglycan Binding
Serpin Family Protein Binding
Biological Process
Activation Of MAPK Activity
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
T Cell Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Cell Population Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Kinase Activity
Response To Interferon-gamma
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Proteolysis
Immune Response
Protein Autoprocessing
Fusion Of Virus Membrane With Host Plasma Membrane
Receptor-mediated Endocytosis Of Virus By Host Cell
Antigen Processing And Presentation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Extracellular Matrix Disassembly
Collagen Catabolic Process
Zymogen Activation
Enkephalin Processing
Fusion Of Virus Membrane With Host Endosome Membrane
CD4-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Keratinocyte Differentiation
Viral Entry Into Host Cell
Antigen Processing And Presentation Of Peptide Antigen
Proteolysis Involved In Cellular Protein Catabolic Process
Elastin Catabolic Process
Macrophage Apoptotic Process
Cellular Response To Thyroid Hormone Stimulus
Pathways
Cell surface interactions at the vascular wall
MHC class II antigen presentation
Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Attachment and Entry
Attachment and Entry
Attachment and Entry
Drugs
L-cysteic acid
Felbinac
Fostamatinib
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
44 interacting genes:
APP
BET1
C14orf180
CCR1
CD1D
CD44
CLDN19
CLEC7A
CMTM7
CTSF
CTSL
EDDM3B
ERG28
FDFT1
FXYD6
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
LPAR3
MAP3K1
MIF
PGA4
PLP1
PLPP4
POMGNT1
PTCH1
RTP2
SEC22A
SERP1
SLC35B1
SMIM1
TEX11
TMEM120B
TMEM243
TMEM254
TMEM60
TMEM97
UPK2
28 interacting genes:
ARSA
BAG6
BTN3A3
CD7
CD74
COL18A1
CST3
CST7
CSTA
CSTB
CTSC
CUX1
CXCL8
EED
GCG
GEM
IGFBP3
KNG1
MCPH1
PLAU
PPP1CC
RELB
RXRA
SERPINB13
SERPINB3
SGTA
SLPI
TG
Entrez ID
972
1514
HPRD ID
00825
00293
Ensembl ID
ENSG00000019582
ENSG00000135047
Uniprot IDs
P04233
A0A024R276
P07711
Q9HBQ7
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
1CJL
1CS8
1ICF
1MHW
2NQD
2VHS
2XU1
2XU3
2XU4
2XU5
2YJ2
2YJ8
2YJ9
2YJB
2YJC
3BC3
3H89
3H8B
3H8C
3HHA
3HWN
3IV2
3K24
3KSE
3OF8
3OF9
4AXL
4AXM
5F02
5I4H
5MAE
5MAJ
5MQY
6EZP
6EZX
6F06
6JD0
6JD8
Enriched GO Terms of Interacting Partners
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