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CD74 and TMEM120B
Data Source:
BioGRID
(two hybrid)
CD74
TMEM120B
Description
CD74 molecule
transmembrane protein 120B
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Cellular_component
Nuclear Inner Membrane
Membrane
Integral Component Of Membrane
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Folding Chaperone
Nitric-oxide Synthase Binding
Molecular_function
Ion Channel Activity
Protein Binding
Biological Process
Activation Of MAPK Activity
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
T Cell Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Cell Population Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Kinase Activity
Response To Interferon-gamma
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Biological_process
Ion Transmembrane Transport
Fat Cell Differentiation
Protein Heterooligomerization
Pathways
Cell surface interactions at the vascular wall
MHC class II antigen presentation
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Blood protein levels (
29875488
)
HDL cholesterol levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Mean platelet volume (
24026423
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Molybdenum levels (
26025379
)
Neutrophil count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
White blood cell count (
32888494
)
Interacting Genes
44 interacting genes:
APP
BET1
C14orf180
CCR1
CD1D
CD44
CLDN19
CLEC7A
CMTM7
CTSF
CTSL
EDDM3B
ERG28
FDFT1
FXYD6
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
LPAR3
MAP3K1
MIF
PGA4
PLP1
PLPP4
POMGNT1
PTCH1
RTP2
SEC22A
SERP1
SLC35B1
SMIM1
TEX11
TMEM120B
TMEM243
TMEM254
TMEM60
TMEM97
UPK2
56 interacting genes:
ALOX5AP
ANKS6
APOA5
AQP6
AQP8
BNIP3L
CCNDBP1
CD74
COMT
CPLX4
CREB3L1
EBP
ERGIC3
FCER1G
FFAR2
FKBP7
GAD2
GJB1
GORAB
GPR152
GPRC5D
GPX8
HSD17B11
IFNGR2
IL7R
JAGN1
JPH1
KCNJ6
LMNA
LRRTM2
MGST3
MRPS18B
MUC1
NCAPH2
REEP2
REEP4
RETREG3
RNF19B
RNF5
SCN3B
SH3GL3
SLC10A1
SLC10A6
SLC17A8
SLC18A1
SLC1A3
STOM
STX2
TLCD4
TMEM139
TMEM143
TMEM14B
TMEM80
TMPRSS2
TMX2
ZDHHC15
Entrez ID
972
144404
HPRD ID
00825
19119
Ensembl ID
ENSG00000019582
ENSG00000188735
Uniprot IDs
P04233
A0PK00
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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