MIF and STRN4

Data Source:
HPRD (two hybrid)

		MIF	STRN4
Description		macrophage migration inhibitory factor	striatin 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Membrane Dendrite Dendritic Spine FAR/SIN/STRIPAK Complex
	Molecular Function	Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity	Protein Binding Calmodulin Binding Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Inflammatory Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Interleukin-12-mediated Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Neutrophil Degranulation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Chemotaxis Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Biological_process
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323)	Chronic lymphocytic leukemia ( 18758461 28165464) Primary sclerosing cholangitis ( 23603763)
Interacting Genes		13 interacting genes: BEX3 BNIPL CD74 COPS5 COPS6 EGFR GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408	23 interacting genes: AK5 ASNS CALM1 CAV1 CLDN12 CRK DDX39B DFFA ECSIT GDF9 JUN KLHDC2 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PLPPR3 PPBP SLC25A6 WIPI2 WNT7A
Entrez ID		4282	29888
HPRD ID		01091	18125
Ensembl ID		ENSG00000240972	ENSG00000090372
Uniprot IDs		I4AY87 P14174	B3KPF6 Q59GV6 Q9NRL3
PDB IDs		1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG
Enriched GO Terms of Interacting Partners?
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