CTSL and CTSC

Data Source:
HPRD (in vitro)

		CTSL	CTSC
Description		cathepsin L	cathepsin C
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Apical Plasma Membrane Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Nucleoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein Self-association Chaperone Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Immune Response Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Keratinocyte Differentiation Viral Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Cellular Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	T Cell Mediated Cytotoxicity Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Immune Response Aging Response To Organic Substance Negative Regulation Of Myelination Neutrophil Degranulation COPII Vesicle Coating Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Attachment and Entry	COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation
Drugs		L-cysteic acid Felbinac Fostamatinib
Diseases			Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS			Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		28 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	3 interacting genes: CAPN1 CTSL XRN2
Entrez ID		1514	1075
HPRD ID		00293	03841
Ensembl ID		ENSG00000135047	ENSG00000109861
Uniprot IDs		A0A024R276 P07711 Q9HBQ7	P53634
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8	1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?
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