ULK2 and POLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ULK2	POLA2
Description		unc-51 like autophagy activating kinase 2	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Cytoplasmic Vesicle Membrane Phagophore Assembly Site Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Molecular_function DNA Binding Protein Binding
	Biological Process	Autophagy Signal Transduction Response To Starvation Protein Autophosphorylation Axon Extension Positive Regulation By Symbiont Of Host Autophagy	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Fostamatinib	Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		15 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		9706	23649
HPRD ID		10556	10160
Ensembl ID		ENSG00000083290	ENSG00000014138
Uniprot IDs		Q8IYT8	Q14181
PDB IDs		6QAT 6QAU 6QAV 6YID	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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