PTGES and EHHADH

Data Source:
BioGRID (two hybrid)

		PTGES	EHHADH
Description		prostaglandin E synthase	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Glutathione Binding Prostaglandin-E Synthase Activity	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Enzyme Binding
	Biological Process	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Organic Cyclic Compound Sensory Perception Of Pain Cyclooxygenase Pathway Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Regulation Of Inflammatory Response Response To Calcium Ion Cellular Oxidant Detoxification	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases
GWAS		Asthma ( 27611488) Pars orbitalis volume ( 31530798)	Cognitive performance ( 19734545) Major depressive disorder ( 27519822 21042317)
Interacting Genes		18 interacting genes: BET1 C4orf3 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A	100 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES EMP1 ERGIC1 FGF14 FUNDC1 GAS8 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD6 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17 ZRANB1
Entrez ID		9536	1962
HPRD ID		05528	06125
Ensembl ID		ENSG00000148344	ENSG00000113790
Uniprot IDs		O14684	Q08426
PDB IDs		3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
Enriched GO Terms of Interacting Partners?
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