PTGES and PTGER2

Data Source:
HPRD (in vivo)

		PTGES	PTGER2
Description		prostaglandin E synthase	prostaglandin E receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Glutathione Binding Prostaglandin-E Synthase Activity	Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Organic Cyclic Compound Sensory Perception Of Pain Cyclooxygenase Pathway Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Regulation Of Inflammatory Response Response To Calcium Ion Cellular Oxidant Detoxification	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Gastric Mucosal Blood Circulation
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Alprostadil Dinoprostone Misoprostol Gemeprost Limaprost
Diseases
GWAS		Asthma ( 27611488) Pars orbitalis volume ( 31530798)
Interacting Genes		18 interacting genes: BET1 C4orf3 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A	3 interacting genes: PTGDS PTGES PTGFR
Entrez ID		9536	5732
HPRD ID		05528	08905
Ensembl ID		ENSG00000148344	ENSG00000125384
Uniprot IDs		O14684	P43116
PDB IDs		3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
Enriched GO Terms of Interacting Partners?
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