CD34 and AGR2

Data Source:
BioGRID (two hybrid)

		CD34	AGR2
Description		CD34 molecule	anterior gradient 2, protein disulphide isomerase family member
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Protein Binding Transcription Factor Binding Carbohydrate Binding Sulfate Binding	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Cell-matrix Adhesion Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Negative Regulation Of Blood Coagulation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Cell Motility Regulation Of Immune Response Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Cell-cell Adhesion Negative Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Death Positive Regulation Of Vasculogenesis	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related macular degeneration ( 23326517) Automobile speeding propensity ( 30643258) Drug experimentation measurement ( 30718321) Estimated glomerular filtration rate ( 31152163) Febrile seizures (MMR vaccine-related) ( 25344690) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Refractive error ( 32231278) Resting heart rate ( 27798624 20639392) RR interval (heart rate) ( 30679814) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		4 interacting genes: AGR2 CHST4 CRKL PRKCD	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		947	10551
HPRD ID		00790	05896
Ensembl ID		ENSG00000174059	ENSG00000106541
Uniprot IDs		P28906	O95994 Q4JM46
PDB IDs			2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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