AGR2 and FAM110A

Data Source:
BioGRID (two hybrid)

		AGR2	FAM110A
Description		anterior gradient 2, protein disulphide isomerase family member	family with sequence similarity 110 member A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Spindle Pole Cytoplasm Microtubule Organizing Center
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Obesity-related traits ( 23251661) Prostate cancer ( 31562322)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	52 interacting genes: AGR2 BICD2 CCNDBP1 CDR2 COG4 COG6 CSNK1E CTDSP1 CTNNA3 DYNC1I1 EFEMP1 EFEMP2 FHL3 FSD2 GOLGA2 GOLGA6L9 HOOK2 HSF2BP KRT15 KRT27 KRT31 KRT34 KRT37 KRT38 KRT39 KRTAP10-8 LDOC1 LIX1 MEIS3 MIF4GD MKRN3 MTUS2 MYOG PFDN5 PNMA1 PYGM RASSF10 RASSF3 RCN1 RINT1 ROPN1 STX11 TCF4 TRIM23 TRIM27 TRIM54 TRIM69 TSC1 TSG101 USHBP1 VPS52 ZSCAN4
Entrez ID		10551	83541
HPRD ID		05896	12775
Ensembl ID		ENSG00000106541	ENSG00000125898
Uniprot IDs		O95994 Q4JM46	Q9BQ89
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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