AGR2 and CYB5R2

Data Source:
BioGRID (two hybrid)

		AGR2	CYB5R2
Description		anterior gradient 2, protein disulphide isomerase family member	cytochrome b5 reductase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Nucleus Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding FAD Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Bicarbonate Transport Sterol Biosynthetic Process
Pathways			Erythrocytes take up carbon dioxide and release oxygen
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Blood pressure ( 23972371) Malaria ( 31844061) Metabolite levels ( 23823483)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	20 interacting genes: AGR2 CDC23 COIL FANCL FFAR2 GOLGA2 HGS MED20 MEOX2 NFKBID PSMC6 REL SUOX TRAF1 TRAF2 TRIM55 TRIM63 TRIP13 YPEL3 ZNF778
Entrez ID		10551	51700
HPRD ID		05896	06435
Ensembl ID		ENSG00000106541	ENSG00000166394
Uniprot IDs		O95994 Q4JM46	A8K237 Q6BCY4
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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