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AGR2 and RUVBL2
Data Source:
BioGRID
(affinity chromatography technology, two hybrid, affinity chromatography technology)
AGR2
RUVBL2
Description
anterior gradient 2, protein disulphide isomerase family member
RuvB like AAA ATPase 2
Image
GO Annotations
Cellular Component
Extracellular Space
Endoplasmic Reticulum
Euchromatin
Swr1 Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Membrane
Nuclear Matrix
Ino80 Complex
NuA4 Histone Acetyltransferase Complex
Extracellular Exosome
MLL1 Complex
R2TP Complex
Ribonucleoprotein Complex
Molecular Function
Dystroglycan Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
Identical Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
TFIID-class Transcription Factor Complex Binding
DNA Helicase Activity
Transcription Corepressor Activity
Protein Binding
ATP Binding
Beta-catenin Binding
ATPase Activity
TBP-class Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
5'-3' DNA Helicase Activity
ADP Binding
Unfolded Protein Binding
ATPase Binding
Biological Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cell-substrate Adhesion
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Digestive Tract Morphogenesis
Positive Regulation Of Developmental Growth
Negative Regulation Of Cell Death
Mucus Secretion
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Positive Regulation Of PERK-mediated Unfolded Protein Response
Box C/D SnoRNP Assembly
DNA Repair
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Folding
Histone Acetylation
DNA Duplex Unwinding
Cellular Response To UV
Positive Regulation Of Histone Acetylation
Regulation Of Growth
Histone H4 Acetylation
Histone H2A Acetylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Establishment Of Protein Localization To Chromatin
Cellular Response To Estradiol Stimulus
Transcriptional Activation By Promoter-enhancer Looping
Negative Regulation Of Estrogen Receptor Binding
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways
Telomere Extension By Telomerase
HATs acetylate histones
Drugs
Quercetin
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) (
23648065
)
Iron status biomarkers (ferritin levels) (
28334935
)
Residual cognition (
28441426
)
Type 2 diabetes (dietary heme iron intake interaction) (
23386860
)
Blood protein levels (
28240269
)
Interacting Genes
87 interacting genes:
ANKRD11
APOBEC3B
APP
ASPH
BORCS8
BORCS8-MEF2B
BRD7
C3
CAMLG
CATSPER1
CCDC90B
CD34
CD68
CDKN2AIPNL
CETN3
CKAP2
CLIC3
CNNM3
CPNE6
CRCP
CREB1
CRMP1
CRYGA
CYB5R2
DAG1
DCAF11
EIF3F
FABP2
FAM110A
FAM117B
GET3
GPSM2
GRB2
GUCA1A
HCK
HMG20A
HSD3B7
IL36RN
IMPDH2
KLHL38
KRT31
LSM1
LYPD3
MBD3
MBLAC1
MED31
MLH1
NDUFB2
NRF1
NRIP1
NSD1
NTAQ1
NUP54
NUP58
NUP62CL
OSTF1
PHC3
POGZ
POLR2L
POM121
PSMA1
PSMB1
PSORS1C2
PTTG2
RBFOX1
RBP5
RIIAD1
RTL4
RUVBL2
SDC3
SGTA
SGTB
SH2D1B
STK16
TCEA2
TFAP2D
THOC1
TLE5
TMEM123
TRAF2
TSTD2
UBE2I
UBQLN1
UBQLN2
UBQLN4
USP20
VEZF1
31 interacting genes:
AGR2
APP
APPL1
APPL2
ATF2
BCL3
CCDC103
CDKN2A
CTNNB1
DNAJB4
DPCD
EHMT2
EP300
EXOSC10
FBL
FDFT1
HDAC1
HDAC4
LIG4
LNX1
MCPH1
MDM2
MYC
NDRG1
RUVBL1
STOM
TAF9
TBP
TERT
YWHAQ
YY1
Entrez ID
10551
10856
HPRD ID
05896
16070
Ensembl ID
ENSG00000106541
ENSG00000183207
Uniprot IDs
O95994
Q4JM46
B3KNL2
Q9Y230
PDB IDs
2LNS
2LNT
2CQA
2XSZ
3UK6
5OAF
6FO1
6H7X
6HTS
6IGM
6K0R
6QI8
6QI9
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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