EPSTI1 and PPM1D

Data Source:
BioGRID (two hybrid)

		EPSTI1	PPM1D
Description		epithelial stromal interaction 1	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function		Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process		G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways			Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Dimensional psychopathology (Arousal) ( 29496196) Heel bone mineral density ( 30598549) Irritable bowel syndrome ( 29626450) Obesity-related traits ( 23251661) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309) Severe aplastic anemia ( 32004448)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		13 interacting genes: AKT1 AURKA BAG4 BCAR3 CASP8 ESR1 FGFR4 FZR1 NOTCH2 PPM1D PTPRJ RB1CC1 VCP	24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		94240	8493
HPRD ID		06309	05482
Ensembl ID		ENSG00000133106	ENSG00000170836
Uniprot IDs		Q96J88	A0A0S2Z4M2 O15297
PDB IDs
Enriched GO Terms of Interacting Partners?
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