FAM189A2 and OPTN

Data Source:
BioGRID (two hybrid)

		FAM189A2	OPTN
Description		family with sequence similarity 189 member A2	optineurin
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein C-terminus Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Biological_process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy
Pathways			Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Coronary artery disease in type 1 diabetes ( 29695241)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)
Interacting Genes		10 interacting genes: BAG3 CALCOCO2 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2	69 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CLTC CMYA5 DAZAP2 DYSF DZIP1 FAM189A2 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNX6 TBC1D15 TBC1D17 TNIP1 UBB UBC UQCRQ USP2 VCP WASHC3 WIPI2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711
Entrez ID		9413	10133
HPRD ID		16255	03891
Ensembl ID		ENSG00000135063	ENSG00000123240
Uniprot IDs		A0A0A0MR12 A0A6F8PH59 Q15884 Q8WU02	Q96CV9
PDB IDs			2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
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