GRHPR and GLS2

Data Source:
BioGRID (two hybrid)

		GRHPR	GLS2
Description		glyoxylate and hydroxypyruvate reductase	glutaminase 2
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GO Annotations	Cellular Component	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Glycerate Dehydrogenase Activity Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP+) Activity Protein Homodimerization Activity NAD Binding NADPH Binding	Glutaminase Activity Protein Binding
	Biological Process	Excretion Cellular Nitrogen Compound Metabolic Process Glyoxylate Metabolic Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Cellular Amino Acid Biosynthetic Process Glutamate Secretion Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process
Pathways		Glyoxylate metabolism and glycine degradation	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases		Primary hyperoxaluria (HP)
GWAS		Bipolar disorder ( 31043756) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)	Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		6 interacting genes: CDC7 FOS GLS2 LIG4 LSM1 PTH2R	14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 PAG1 PATJ RALA RGS3 SNTA1 TAX1BP3 XAF1
Entrez ID		9380	27165
HPRD ID		05052	05901
Ensembl ID		ENSG00000137106	ENSG00000135423
Uniprot IDs		A0A384N605 Q9UBQ7	A0A087X004 Q9UI32
PDB IDs		2GCG 2H1S 2Q50 2WWR	4BQM 5U0K
Enriched GO Terms of Interacting Partners?
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