GLS2 and TAX1BP3

Data Source:
HPRD (two hybrid, in vitro)

		GLS2	TAX1BP3
Description		glutaminase 2	Tax1 binding protein 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Fibrillar Center Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Glutaminase Activity Protein Binding	Protein Binding Beta-catenin Binding Protein C-terminus Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Cellular Amino Acid Biosynthetic Process Glutamate Secretion Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Activation Of GTPase Activity Negative Regulation Of Protein Localization To Cell Surface
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	RHO GTPases Activate Rhotekin and Rhophilins
Drugs		Glutamic acid
Diseases
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 PAG1 PATJ RALA RGS3 SNTA1 TAX1BP3 XAF1	13 interacting genes: ARNT2 CDK5RAP3 CTNNB1 DTX1 GATA1 GLS GLS2 PLK4 RNF183 RTKN STAU1 TCEA2 TRIM29
Entrez ID		27165	30851
HPRD ID		05901	18160
Ensembl ID		ENSG00000135423	ENSG00000213977
Uniprot IDs		A0A087X004 Q9UI32	A0A087X282 O14907
PDB IDs		4BQM 5U0K	2KG2 2L4S 2L4T 2VZ5 3GJ9 3SFJ 4E3B 4NNL 4NNM
Enriched GO Terms of Interacting Partners?
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