GLS2 and GRHPR

Data Source:
BioGRID (two hybrid)

		GLS2	GRHPR
Description		glutaminase 2	glyoxylate and hydroxypyruvate reductase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex
	Molecular Function	Glutaminase Activity Protein Binding	Glycerate Dehydrogenase Activity Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP+) Activity Protein Homodimerization Activity NAD Binding NADPH Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Cellular Amino Acid Biosynthetic Process Glutamate Secretion Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Excretion Cellular Nitrogen Compound Metabolic Process Glyoxylate Metabolic Process
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Glyoxylate metabolism and glycine degradation
Drugs		Glutamic acid
Diseases			Primary hyperoxaluria (HP)
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 PAG1 PATJ RALA RGS3 SNTA1 TAX1BP3 XAF1	6 interacting genes: CDC7 FOS GLS2 LIG4 LSM1 PTH2R
Entrez ID		27165	9380
HPRD ID		05901	05052
Ensembl ID		ENSG00000135423	ENSG00000137106
Uniprot IDs		A0A087X004 Q9UI32	A0A384N605 Q9UBQ7
PDB IDs		4BQM 5U0K	2GCG 2H1S 2Q50 2WWR
Enriched GO Terms of Interacting Partners?
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