GLS2 and DLG3

Data Source:
HPRD (in vitro)

		GLS2	DLG3
Description		glutaminase 2	discs large MAGUK scaffold protein 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction
	Molecular Function	Glutaminase Activity Protein Binding	Protein Binding Kinase Binding Phosphatase Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Cellular Amino Acid Biosynthetic Process Glutamate Secretion Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Glutamic acid
Diseases			Non-syndromic X-linked mental retardation
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)	Mean platelet volume ( 32888494)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 PAG1 PATJ RALA RGS3 SNTA1 TAX1BP3 XAF1	48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		27165	1741
HPRD ID		05901	02177
Ensembl ID		ENSG00000135423	ENSG00000082458
Uniprot IDs		A0A087X004 Q9UI32	Q59FY1 Q92796
PDB IDs		4BQM 5U0K	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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