GRHPR and CDC7

Data Source:
BioGRID (two hybrid)

		GRHPR	CDC7
Description		glyoxylate and hydroxypyruvate reductase	cell division cycle 7
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GO Annotations	Cellular Component	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	Glycerate Dehydrogenase Activity Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP+) Activity Protein Homodimerization Activity NAD Binding NADPH Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Excretion Cellular Nitrogen Compound Metabolic Process Glyoxylate Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition
Pathways		Glyoxylate metabolism and glycine degradation	Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases		Primary hyperoxaluria (HP)
GWAS		Bipolar disorder ( 31043756) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)	Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		6 interacting genes: CDC7 FOS GLS2 LIG4 LSM1 PTH2R	52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B
Entrez ID		9380	8317
HPRD ID		05052	10345
Ensembl ID		ENSG00000137106	ENSG00000097046
Uniprot IDs		A0A384N605 Q9UBQ7	A0A384MTU6 B2R6V2 O00311
PDB IDs		2GCG 2H1S 2Q50 2WWR	4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?
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