CYTH3 and CNKSR1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		CYTH3	CNKSR1
Description		cytohesin 3	connector enhancer of kinase suppressor of Ras 1
Image
GO Annotations	Cellular Component	Golgi Membrane Ruffle Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of ARF Protein Signal Transduction Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Regulation Of Catalytic Activity Establishment Of Epithelial Cell Polarity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		Intra-Golgi traffic	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 26426971) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		12 interacting genes: ARFIP2 CALCOCO1 CCDC120 CNKSR1 CYTIP FRMD4B IFI35 INAVA IPCEF1 PIK3CA SYCE1 TAMALIN	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		9265	10256
HPRD ID		05469	11937
Ensembl ID		ENSG00000008256	ENSG00000142675
Uniprot IDs		O43739	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		4KAX 6U3E 6U3G	1WWV
Enriched GO Terms of Interacting Partners?
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