CHMP4C and VPS4A

Data Source:
HPRD (two hybrid)

		CHMP4C	VPS4A
Description		charged multivesicular body protein 4C	vacuolar protein sorting 4 homolog A
Image
GO Annotations	Cellular Component	ESCRT III Complex Multivesicular Body Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Late Endosome Membrane Flemming Body	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding Protein-containing Complex Binding
	Biological Process	Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Abscission Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Negative Regulation Of Cytokinesis Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Mitotic Cytokinesis Checkpoint Regulation Of Viral Process Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Epithelial ovarian cancer ( 25581431) Ovarian cancer ( 23535730)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		10 interacting genes: CC2D1A CHMP4A CHMP4B HMGB3P1 PDCD6IP STAMBP TRPC4AP USP54 USP8 VPS4A	10 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 RND2 VPS4B
Entrez ID		92421	27183
HPRD ID		18135	11676
Ensembl ID		ENSG00000164695	ENSG00000132612
Uniprot IDs		Q96CF2	A0A024R705 Q9UN37
PDB IDs		3C3R 5MK3 5V3R 5WA1	1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?
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