VPS4A and CHMP4C

Data Source:
HPRD (two hybrid)

		VPS4A	CHMP4C
Description		vacuolar protein sorting 4 homolog A	charged multivesicular body protein 4C
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body	ESCRT III Complex Multivesicular Body Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Late Endosome Membrane Flemming Body
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding Protein-containing Complex Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly	Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Abscission Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Negative Regulation Of Cytokinesis Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Mitotic Cytokinesis Checkpoint Regulation Of Viral Process Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Epithelial ovarian cancer ( 25581431) Ovarian cancer ( 23535730)
Interacting Genes		10 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 RND2 VPS4B	10 interacting genes: CC2D1A CHMP4A CHMP4B HMGB3P1 PDCD6IP STAMBP TRPC4AP USP54 USP8 VPS4A
Entrez ID		27183	92421
HPRD ID		11676	18135
Ensembl ID		ENSG00000132612	ENSG00000164695
Uniprot IDs		A0A024R705 Q9UN37	Q96CF2
PDB IDs		1YXR 2JQ9 2K3W	3C3R 5MK3 5V3R 5WA1
Enriched GO Terms of Interacting Partners?
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