VPS4A and CHMP2A

Data Source:
HPRD (two hybrid)

		VPS4A	CHMP2A
Description		vacuolar protein sorting 4 homolog A	charged multivesicular body protein 2A
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body	Chromatin ESCRT III Complex Nuclear Envelope Multivesicular Body Cytosol Membrane Membrane Coat Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding Protein-containing Complex Binding	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding
	Biological Process	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly	Nucleus Organization Mitotic Metaphase Plate Congression Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Nuclear Envelope Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Late Endosome To Vacuole Transport Regulation Of Viral Process Protein Polymerization Protein Homooligomerization Negative Regulation Of Cell Death Midbody Abscission Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		10 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 RND2 VPS4B	13 interacting genes: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B
Entrez ID		27183	27243
HPRD ID		11676	12520
Ensembl ID		ENSG00000132612	ENSG00000130724
Uniprot IDs		A0A024R705 Q9UN37	A0A024R4S0 O43633
PDB IDs		1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?
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