VPS4A and RND2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		VPS4A	RND2
Description		vacuolar protein sorting 4 homolog A	Rho family GTPase 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body	Acrosomal Membrane Early Endosome Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding Protein-containing Complex Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein N-terminus Binding
	Biological Process	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collateral Sprouting
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Coronary artery disease ( 29212778)
Interacting Genes		10 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 RND2 VPS4B	6 interacting genes: ARHGAP5 FNBP1 MEOX2 RACGAP1 UBXN11 VPS4A
Entrez ID		27183	8153
HPRD ID		11676	03332
Ensembl ID		ENSG00000132612	ENSG00000108830
Uniprot IDs		A0A024R705 Q9UN37	P52198
PDB IDs		1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?
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