VPS4A and CHMP1B

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		VPS4A	CHMP1B
Description		vacuolar protein sorting 4 homolog A	charged multivesicular body protein 1B
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body	ESCRT III Complex Nucleoplasm Multivesicular Body Cytosol Endosome Membrane Membrane Coat Midbody Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding Protein-containing Complex Binding	Protein Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly	Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Late Endosome To Vacuole Transport Cell Division Midbody Abscission Regulation Of Mitotic Spindle Assembly ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 RND2 VPS4B	19 interacting genes: CHMP1A CHMP4B CHMP5 CNOT10 KNSTRN MITD1 PICK1 RAB11A RASSF7 SNRNP200 SPAST SSRP1 STAMBP SUCLG1 USP54 USP8 VPS4A VPS4B VTA1
Entrez ID		27183	57132
HPRD ID		11676	12106
Ensembl ID		ENSG00000132612	ENSG00000255112
Uniprot IDs		A0A024R705 Q9UN37	Q7LBR1
PDB IDs		1YXR 2JQ9 2K3W	3EAB 3JC1 4TXQ 4TXR 6E8G 6TZ4 6TZ5 6TZ9
Enriched GO Terms of Interacting Partners?
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