SPSB4 and DDX4

Data Source:
BioGRID (unspecified method)

		SPSB4	DDX4
Description		splA/ryanodine receptor domain and SOCS box containing 4	DEAD-box helicase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	RNA Binding RNA Helicase Activity ATP Binding ATPase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Rhythmic Process Positive Regulation Of Protein Polyubiquitination	Male Meiotic Nuclear Division Male Meiosis I Multicellular Organism Development Gamete Generation Spermatogenesis Negative Regulation Of Transposition Cell Differentiation Flagellated Sperm Motility Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation PiRNA Biosynthetic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Stroke (ischemic) ( 23041239)	Cocaine dependence ( 31212010)
Interacting Genes		3 interacting genes: DDX4 NOS2 PAWR	5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4
Entrez ID		92369	54514
HPRD ID		18108	05593
Ensembl ID		ENSG00000175093	ENSG00000152670
Uniprot IDs		Q96A44	Q9NQI0
PDB IDs		2V24 6DN7 6DN8
Enriched GO Terms of Interacting Partners?
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