DDX4 and SPSB1

Data Source:
BioGRID (unspecified method)

		DDX4	SPSB1
Description		DEAD-box helicase 4	splA/ryanodine receptor domain and SOCS box containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding ATPase Activity	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Multicellular Organism Development Gamete Generation Spermatogenesis Negative Regulation Of Transposition Cell Differentiation Flagellated Sperm Motility Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation PiRNA Biosynthetic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		PIWI-interacting RNA (piRNA) biogenesis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		54514	80176
HPRD ID		05593	18106
Ensembl ID		ENSG00000152670	ENSG00000171621
Uniprot IDs		Q9NQI0	A0A024R4G8 Q96BD6
PDB IDs			2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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