DDX4 and SPSB4

Data Source:
BioGRID (unspecified method)

		DDX4	SPSB4
Description		DEAD-box helicase 4	splA/ryanodine receptor domain and SOCS box containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding ATPase Activity	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Multicellular Organism Development Gamete Generation Spermatogenesis Negative Regulation Of Transposition Cell Differentiation Flagellated Sperm Motility Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation PiRNA Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Rhythmic Process Positive Regulation Of Protein Polyubiquitination
Pathways		PIWI-interacting RNA (piRNA) biogenesis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Stroke (ischemic) ( 23041239)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	3 interacting genes: DDX4 NOS2 PAWR
Entrez ID		54514	92369
HPRD ID		05593	18108
Ensembl ID		ENSG00000152670	ENSG00000175093
Uniprot IDs		Q9NQI0	Q96A44
PDB IDs			2V24 6DN7 6DN8
Enriched GO Terms of Interacting Partners?
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