DDX4 and PIWIL2

Data Source:
HPRD (in vitro, in vivo)

		DDX4	PIWIL2
Description		DEAD-box helicase 4	piwi like RNA-mediated gene silencing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Nucleus Cytoplasm Perinucleolar Chromocenter Chromatoid Body P Granule Pi-body Dense Body PET Complex
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding ATPase Activity	MRNA Binding Endoribonuclease Activity Protein Binding PiRNA Binding Metal Ion Binding Polysome Binding
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Multicellular Organism Development Gamete Generation Spermatogenesis Negative Regulation Of Transposition Cell Differentiation Flagellated Sperm Motility Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation PiRNA Biosynthetic Process	RNA 5'-end Processing Multicellular Organism Development Spermatogenesis Negative Regulation Of Transposition Germ-line Stem Cell Population Maintenance Gene Silencing By RNA PiRNA Metabolic Process Negative Regulation Of Circadian Rhythm DNA Methylation Involved In Gamete Generation Positive Regulation Of Translation Oogenesis Rhythmic Process Meiotic Cell Cycle Positive Regulation Of Meiosis I Positive Regulation Of Histone H3-K14 Acetylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic PiRNA Biosynthetic Process Positive Regulation Of Histone H3-K9 Acetylation
Pathways		PIWI-interacting RNA (piRNA) biogenesis	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	Hypertriglyceridemia ( 23505323)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	3 interacting genes: DDX4 DICER1 TBCB
Entrez ID		54514	55124
HPRD ID		05593	11434
Ensembl ID		ENSG00000152670	ENSG00000197181
Uniprot IDs		Q9NQI0	Q8TC59 W0HK13
PDB IDs			3O7X 3QIR
Enriched GO Terms of Interacting Partners?
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