SPSB4 and PAWR

Data Source:
BioGRID (unspecified method)

		SPSB4	PAWR
Description		splA/ryanodine receptor domain and SOCS box containing 4	pro-apoptotic WT1 regulator
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GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Rhythmic Process Positive Regulation Of Protein Polyubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Stroke (ischemic) ( 23041239)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: DDX4 NOS2 PAWR	16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		92369	5074
HPRD ID		18108	09051
Ensembl ID		ENSG00000175093	ENSG00000177425
Uniprot IDs		Q96A44	Q96IZ0
PDB IDs		2V24 6DN7 6DN8	2JK9
Enriched GO Terms of Interacting Partners?
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