PTTG1 and UBE2C

Data Source:
BioGRID (enzymatic study)

		PTTG1	UBE2C
Description		PTTG1 regulator of sister chromatid separation, securin	ubiquitin conjugating enzyme E2 C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Height ( 31562340)
Interacting Genes		23 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2C UBE2N UBE4A XRCC6	33 interacting genes: ANAPC11 ANAPC2 AURKA CCNA2 CCNB1 CDC20 CKAP2 CXCR1 DTX1 ENO2 FBXO5 FZR1 GMNN ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 PTTG1 RAG1 RELA RNF31 RNF7 TNNC1 TRIM21 TRIM28 TRIM29 TRIM72 UBA1 UBASH3B UBE3D
Entrez ID		9232	11065
HPRD ID		04998	05717
Ensembl ID		ENSG00000164611	ENSG00000175063
Uniprot IDs		O95997 Q6IAL9	A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3
PDB IDs			1I7K 4YII 5A31 5KHR 5L9U
Enriched GO Terms of Interacting Partners?
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