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CD4 and PTPRC
Data Source:
BioGRID
(fluorescent resonance energy transfer)
HPRD
(in vivo)
CD4
PTPRC
Description
CD4 molecule
protein tyrosine phosphatase receptor type C
Image
GO Annotations
Cellular Component
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Clathrin-coated Vesicle Membrane
T Cell Receptor Complex
Membrane Raft
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Integral Component Of Membrane
Secretory Granule Membrane
Bleb
Membrane Raft
Extracellular Exosome
Membrane Microdomain
Molecular Function
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Immunoglobulin Binding
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Signaling Receptor Activity
Interleukin-16 Binding
Interleukin-16 Receptor Activity
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Tyrosine Kinase Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Protein Kinase Binding
Ankyrin Binding
Spectrin Binding
Heparan Sulfate Proteoglycan Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Adaptive Immune Response
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Calcium Ion Transport Into Cytosol
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
T Cell Differentiation
Macrophage Differentiation
Response To Estradiol
Maintenance Of Protein Location In Cell
Positive Regulation Of Interleukin-2 Production
Response To Vitamin D
Positive Regulation Of Kinase Activity
Helper T Cell Enhancement Of Adaptive Immune Response
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
T Cell Selection
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Regulation Of Calcium Ion Transport
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Activation Of MAPK Activity
Natural Killer Cell Differentiation
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Cytotoxicity
Negative Regulation Of Cytokine-mediated Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Immunoglobulin Production
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Leukocyte Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Response To Gamma Radiation
Regulation Of Gene Expression
Viral Process
Dephosphorylation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of B Cell Proliferation
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Autophosphorylation
Regulation Of Interleukin-8 Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
Peptidyl-tyrosine Dephosphorylation
Calcium-mediated Signaling Using Intracellular Calcium Source
T Cell Proliferation
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Neutrophil Degranulation
Positive Regulation Of MAPK Cascade
Cell Cycle Phase Transition
Plasma Membrane Raft Distribution
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Protein Kinase Activity
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Stem Cell Development
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Regulation Of Cell Cycle
Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Tyrosine Phosphatase Activity
Negative Regulation Of Microglial Cell Activation
DN2 Thymocyte Differentiation
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Hematopoietic Stem Cell Migration
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Alpha-defensins
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Vpu mediated degradation of CD4
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
Neutrophil degranulation
Drugs
Antithymocyte immunoglobulin (rabbit)
Clenoliximab
Ibalizumab
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Bone mineral density (hip) (
30172743
)
Response to Vitamin E supplementation (
22437554
)
Apolipoprotein B levels (
32203549
)
Asthma (
31959851
30929738
32296059
31619474
)
Asthma (adult onset) (
30929738
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
26192919
28067908
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
LDL cholesterol levels (
32203549
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
20139978
28017375
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
)
Ulcerative colitis (
24837172
)
Vitiligo (
27723757
)
White blood cell count (
32888494
)
Interacting Genes
38 interacting genes:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCHF4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
45 interacting genes:
ANP32A
CD1D
CD2
CD22
CD247
CD28
CD4
CD8A
CSNK2A1
CSNK2A2
CXCR4
DPP4
EZR
FCGR3A
FYN
GANAB
GRB2
IFNAR1
INSR
IRS1
ITGAL
JAK1
JAK2
JAK3
LCK
LCP2
LGALS1
LSM1
LYN
MAPK1
MBL2
PAEP
PPFIA1
PPFIBP2
PRKCSH
PTPN6
PTPRCAP
RASA1
RNF11
SEMA4D
SKAP1
SRC
TYK2
UHRF2
ZAP70
Entrez ID
920
5788
HPRD ID
01740
01050
Ensembl ID
ENSG00000010610
ENSG00000081237
Uniprot IDs
A0A4Y5UGE4
B0AZV7
B4DT49
P01730
M9MML4
P08575
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3J70
3JCB
3JCC
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4H8W
4JM2
4P9H
4Q6I
4R2G
4R4H
4RQS
5A7X
5A8H
5CAY
5THR
5U1F
5VN3
6CM3
6EDU
6L1Y
6MEO
6MET
6OPN
6OPO
6OPP
6OPQ
6QH6
6QH7
6U0L
6U0N
6URI
6X5B
6X5C
1YGR
1YGU
5FMV
5FN6
5FN7
Enriched GO Terms of Interacting Partners
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